Therapeutic drug levels are lab tests to look for the presence and the amount of a drug in the blood. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Davis on amitriptyline vs nortriptyline: It is generally thought that antidepressants are equally effective in treating depression. Pamelor or nortriptyline, is a tricyclic antidepressants thought to have a therapeutic window. This refers to a range of blood levels. Initial Dosage for Adults: For outpatients 75 mg of amitriptyline HCl a day in divided doses is usually satisfactory. If necessary, this may be increased to a total of 150 mg per day. Amitriptyline Hydrochloride 25mg/5ml Oral Solution - Summary of Product Characteristics (SmPC) by Rosemont Pharmaceuticals Limited Amitriptyline is a tricyclic antidepressant that blocks the reuptake of serotonin at nerve endings and possesses high anticholinergic activity and cardiovascular toxicity. Detailed Amitriptyline dosage information for adults, the elderly and children. Includes dosages for Depression and Depression; plus renal, liver and dialysis adjustments. Clinical Significance. The tricyclics are used to treat depression. Nortriptyline is an active metabolite of Amitriptyline. Therapeutic drug levels are monitored to assist the physician assessing therapeutic response and to avoid toxicity. Amitriptyline hydrochloride USP, a dibenzocycloheptadiene derivative, is a white, or practically white, odorless or practically odorless, crystalline powder or small crystals and freely soluble in water, alcohol, chloroform and methanol and insoluble in ether. Amitriptyline Hydrochloride 10mg/5ml Oral Solution - Summary of Product Characteristics (SmPC) by Wockhardt UK Ltd Learn about Elavil (Amitriptyline) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.